米非司酮不同给药途径终止妊娠的临床观察

目的观察米非司酮分次舌下含服与口服给药配伍米索前列醇对中止8～16周妊娠的有效性和安全性。方法选择8～16周无任何米非司酮和米索前列醇禁忌证要求中止妊娠的病例68例,随机分为A组和B组,A组舌下含服米非司酮,B组口服米非司酮,末次米非司酮用药1.5～2.0h后,两组均阴道后穹窿放置米索前列醇0.2mg。结果A组有效率100%,完全流产率94%;B组有效率100%,完全流产率91%,流产后阴道流血量与平时月经量相似,舌下含服给药更能减少恶心、呕吐等胃肠道副反应。结论米非司酮舌下含服配伍米索前列醇用于8～16周妊娠引产安全、有效,且能减少胃肠道副反应,对早孕反应严重的病例尤为适用。

Objective To investigate the effects of mifepristone fractionated sublingual and oral administration in combination with misoprostol for termination of pregnancy 8～16w ef？cacy and safety. Methods no 8～16w ban mifepristone and misoprostol disease cases require the suspension of 68 cases of pregnancy, were randomly divided into A group and B group, A mifepristone sublingual group, B group oral m one non-Division, the last 1.5～2 hours after mifepristone administration, the two groups were placed posterior fornix vaginal misoprostol 0.2mg. Results the efficien in A group was one hundred percent, complete abortion rate was 94%, the volume of vaginal bleeding after abortion with a similar volume of normal menstruation; the efficien in B group was 100% ,complete abortion rate was 91%, the volume of vaginal bleeding after abortion with a similar volume of normal menstruation. sublingual administration can reduce nausea, vomiting and other gastrointestinal side effects. Conclusions sublingual mifepristone and misoprostol for labor induction 8～16w pregnancy safe, effective, and can reduce gastrointestinal side effects, response to serious cases of early pregnancy is particularly applicable.