矽肺患者血清CC16蛋白的检测及临床意义

目的探讨矽肺患者血清CC16蛋白水平的变化及意义。方法应用ELISA方法测定19例I期、15例II期、8例III期矽肺患者和32例健康人血清中CC16蛋白水平的变化。结果与对照组相比,矽肺组血清中CC16水平明显降低(P<0.05);其中I期矽肺组血清中CC16含量的降低最为显著(P<0.01)。结论检测矽肺患者血清CC16水平对了解患者病情的发生和发展、临床诊断和预后判断具有重要的临床意义。

Objective To study the clinical significance of serum CC16 levels in patients with silicosis. Methods The contents of serum CC16 protein in 19 patients with first stage silicosis, 15 patients with second stage silicosis, 8 patients with third stage silicosis as well as 32 controls were detected by enzyme linked immunosorbent assay （ELISA）. Results Serum levels of CC 16 in patients with silicosis were significantly lower than those in the controls （P〈0.05）, and the serum CC16 contents in the first stage patients were significantly lower than those in the second and third stage silicosis （P〈0.01）. Conclusion The dectection of serum levels of CC16 in silicosis patients has an important clinical significance in studying the occurrence and progress, clinical diagnose and prognosis prediction of silicosis.