吉西他滨联合顺铂治疗晚期乳腺癌的临床观察

Clinical observation of 47 patients with advanced breast cancer treated with gemcitabine combined with cisplatin

目的观察吉西他滨联合顺铂治疗晚期乳腺癌的疗效及不良反应。方法47例晚期乳腺癌患者采用吉西他滨1000mg/m2,静脉滴注30min,d1,d8;顺铂25～40mg/m2,d2～4。21d一周期,治疗2周期后评价疗效及不良反应。结果47例均可评价疗效,共完成周期数为206个。完全缓解(CR)4例,部分缓解(PR)17例,稳定(SD)15例,进展(PD)11例,总有效率(CR+PR)44.7%,疾病控制率(CR+PR+SD)76.6%,中位疾病进展时间8.7个月,中位生存期为12.3个月(2.0～52.5个月)。主要不良反应为骨髓抑制、胃肠道反应。结论吉西他滨联合顺铂治疗晚期乳腺癌疗效较好,毒副反应轻,耐受性好,是晚期乳腺癌的有效治疗方案。

Objective To study the efficacy and toxic effects of gemcitabine combined with cisplatin in treating patients with advanced breast cancer.Methods Forty-seven patients with advanced breast cancer were treated with gemcitabine 1000 mg/m^2 on day1and day8,cisplatin 25-40 mg/m^2on days 2-4.The chemotherapy repeated every 3 weeks.Efficacy and toxic reactions were reviewed after 2 cycles of chemotherapy.Results Forty-seven patients were evaluable for response：CR 4 cases,PR 17cases,SD 15cases,and PD 11cases.The overall response rate（ORR） was 44.7% and the disease control rate（DCR） was 76.6%.The median time to progression（TTP） was 8.7 months,and median survival time（OS） was 12.3 months.The main toxic reactions included myelosuppression,gastrointestinal toxic reactions.Conclusion Gemcitabine combined with cisplatin is effective in the treatment of patients with advanced breast cancer,the toxic reaction is acceptable.It may be an effective regimen.