术后确诊的小细胞肺癌联合放化疗疗效分析

Efficacy of radiotherapy and chemotherapy in treatment of small cell lung cancer confirmed after operation-Analysis of treatment in 44 patients

目的回顾性总结及评价手术后确诊的小细胞肺癌(SCLC)患者44例联合放化疗治疗的疗效。方法44例SCLC患者中,Ⅰ期15例(34.1%),Ⅱ期13例(29.6%),Ⅲ期12例(27.3%),Ⅳ期4例(9.1%),除肺段切除1例外均行肺叶或全肺切除,术后均用"依托泊苷+顺铂或卡铂"或"紫杉醇+顺铂或卡铂"方案化疗4～8个疗程,分别随访1,3,5年生存率。结果44例小细胞肺癌(SCLC)患者的1,3,5年总的生存率分别为84.3%、48.2%和18.1%。Ⅰ期、Ⅱ期患者采用术后联合放、化疗,可以获得较好疗效,Ⅲ期、Ⅳ期患者首选手术对生存率无益。结论手术后联合放、化疗对Ⅰ～II期的SCLC具有良好的治疗效果。

Objective To analyze and evaluate retrospectively the efficacy of chemotherapy and radiotherapy in 44 patients with small cell lung cancer（SCLC） confirmed after operation.Methods Fortyfour patients with SCLC：stage Ⅰ,15 cases（34.1%）,stage Ⅱ,13 cases（29.6%）,stage Ⅲ,12 cases（27.3%） and stageⅣ,4 cases（9.1%） were analyzed.All of them had undergone radical operation except 1 segmentectomy case,and all received chemotherapy for 4-8 cycles with＂etoposide ＋ cisplatin or carboplatin＂or＂taxinol ＋ cisplatin or carboplatin＂regimen after operation.The patients were followed up for 1,3,5year survival rates.Results The 1,3,5-year survival rates of 44 cases were 84.3%,48.2% and 18.1% respectively.The efficacy of the postoperative treatment with combined chemotherapy and radiotherapy for stageⅠandⅡcases was good,but was not useful for stage Ⅲ and Ⅳ cases.Conclusion Postoperative treatment with combined chemotherapy and radiotherapy had good therapeutic effects for stagesⅠandⅡ SCLC.