摘要
目的研究多西紫杉醇(希存)联合顺铂及5-Fu治疗进展期胃癌的近期疗效及不良反应。方法58例进展期胃癌患者随机分两组,DCF方案为治疗组(30例),ECF方案为对照组(28例)。结果DCF方案组有效率为36.6%(11/30),对照组有效率28.5%(8/28),两者差异无显著性(P>0.05)。毒副反应主要表现为白细胞减少、恶心、呕吐和脱发,两组相比较差异无显著性。结论DCF方案治疗晚期胃癌疗效较好,毒副反应可耐受。
Objective To evaluate the clinica1 efficacy and toxicity of docetaxo1 plus5Fu and cisplatin in the treatment of advanced gastric cancer.Methods Fifty-eight patients with advanced gastric cancer were randomly divided into 2groups.One group received docetaxol,5-Fu and cisplatin（DCF regimen,trial group）,the other received epirubicin,5-Fu and cisplatin（ECF regimen,control group）.Both regimens were repeated every 3 weeks.Results The tota1 response rate（CR ＋ PR） was 36.6%（11 /30） in the trial group,and 28.5%（8 /28） in the control group.There was no significant difference between 2 groups（P 〉 0.05）.The main toxicity had no significant difference between 2 groups.Conclusion Docetaxol plus 5Fu and cisplatin were effective in treating advanced gastric cancer,the toxicity is mild and tolerable for most patients.
出处
《中国肿瘤临床与康复》
2010年第1期59-61,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
