参芪五味子片治疗高考前焦虑症113例临床观察

Clinical Observation on Shenqi Wuweizi Tablet for Anxiety before College Entrance Examination:A Report of 113 Cases

目的观察参芪五味子片治疗高考前焦虑症的临床疗效与不良反应。方法将227例高考前焦虑症患者随机分为治疗组113例和对照组114例,治疗组口服参芪五味子片,每次3片,每日3次;对照组口服阿普唑仑片,每次0.4mg,每日3次,两组疗程均为6周。两组均于治疗前及治疗后第1、2、4、6周末采用汉密尔顿焦虑量表(HAMA)、临床总体印象量表(CGI)、焦虑自评量表(SAS)评定临床疗效,同时观察不良反应。结果治疗后1周对照组HAMA积分与治疗前比较显著下降(P<0.05),并且较治疗组低(P<0.05)。治疗2、4、6周后,两组患者HAMA积分、CGI积分、SAS积分与治疗前比较均有显著下降(P<0.01),并且治疗后6周时治疗组HAMA、SAS积分明显低于对照组(P<0.01)。治疗组显效率70.8%,有效率88.5%;对照组显效率73.7%,有效率89.4%。治疗组仅1例出现恶心,对照组不良反应57例。结论两组患者临床疗效相当,阿普唑仑较参芪五味子片显效快,参芪五味子片比阿普唑仑作用持久,参芪五味子片尚未发现明显不良反应。

Objective To observe the effect of ShenQi Wuweizi Tablet （Tablet composed of pilose asiabell root, astragalus root, and sehisandra fruit） on anxiety before college entrance examination. Methods Totally 227 patients were randomized into a treatment group （113 cases, treated with Shenqi Wuweizi Tablet, 3 tablets each time and 3 time a day）, and a control group （114 cases, treated with alprazolam, 0.4 mg each time and 3 times a day）. The treatment course was 6 weeks for both groups. Before treatment and at the end of the 1st, 2nd, 4th and 6th week of treatment, the clinical effect was assessed with Hamilton Anxiety Scale （HAMA） and Clinical Global Impression （CGI）, and Self-Rating Anxiety Scale （SAS）. And at the same time, the untoward reactions was also observed. Results At the end of the 1st week of treatment, the HAMA score was significantly decreased in the control group （P〈 0. 05）, lower than that of the treatment group （P〈0.05）. At the end of the 2nd, 4th and 6th week, the HAMA scores, CGI scores, and SAS scores of both groups were significantly decreased （P〈0. 01）; and at the end of the 6th week, the HAMA score and SAS score of the treatment group were significantly lower than those of the control group （P〈0.01）. The remarkably effective rate of the treatment group was 70.8% and the effective rate 88. 5%, while those of the control group were 73.7% and 89.4% respectively. There was only 1 case, in the treatment group, who had nausea, but 57 cases in the control group had untoward reactions. Conclusion The effect of the two groups is equivalent. Alprazolam shows the effect faster than Shenqi Wuweizi Tablet, and the latter has the effect longer and without obvious untoward reactions.