1,25(OH)_2D_3缺乏对小鼠脂多糖诱导的应激反应的影响
Effect of 1,25(OH)_2D_3 on the Stress Reaction Induced by Lipopolysaccharide
摘要
自发现一些免疫细胞上存在维生素D受体（vitamin D receptor，VDR），维生素D（VD）对免疫调节的研究成为热点。巨噬细胞是一类重要的免疫细胞，受刺激后可产生炎性细胞因子，如肿瘤坏死因子（tumor necrosis factor-alpha，TNF-α）、一氧化氮（nitricoxide，NO）等。脂多糖（1ipopolysaccharide，LPS）是革兰阴性细菌细胞壁外膜上的主要结构成分，是其主要的致病因子，可刺激内皮细胞、巨噬细胞、成纤维细胞产生大量的炎性细胞因子（TNF-α、NO、IL-6等）。
出处
《营养学报》
CAS
CSCD
北大核心
2010年第1期91-92,共2页
Acta Nutrimenta Sinica
基金
国家自然科学基金(No.30570883)
苏州大学大学生课外学术科研基金(No.KY2008093A)
中国博士后科学基金(No.20070410767)
参考文献5
-
1Veldman CM, Cantorna MT, DeLuca HF. Expression of 1, 25-dihydroxyvitamin D3 receptor in the immune system[J]. Arch Biochem Biophys, 2000, 374: 334-338.
-
2Cohen ML, Douvdevani A, Chaimovitz C, et al. Regulation of TNF-alpha by 1-alpha, 25-dihydroxyvitamin D3 in human macrophages from CAPD patients[J]. Kidney lnt, 2001, 59: 69--75.
-
3Trent MS, Stead CM, Tran hX, et al. Diversity of endotoxin and its impact on pathogenesis[J]. J Endotoxinges, 2006, 12: 205--223.
-
4张增利,李冰燕,童建.利用基因敲除小鼠研究维生素D在免疫功能发育中的作用[J].中华微生物学和免疫学杂志,2007,27(3):260-263. 被引量：7
-
5Cantorna MT, Zhu Y, Froicu M, etal. Vitamin D status, 1, 25 dihydroxyvitamin D3, and the immune system[J]. Am J Clin Nutr, 2004, 80(Suppl): 1717S--1720S.
二级参考文献12
-
1张秀珍,朱志刚.活性维生素D3.见:张秀珍,李素,主编.内分泌代谢疾病与肾脏[M].上海:复旦大学出版社,2004.36-37.
-
2Haussler MR, Whitfield GK, Haussler CA, et al. The nuclear vitamin D receptor: biological and molecular regulatory properties revealed. J Bone Miner Res, 1998, 13(3): 325-349.
-
3Verstuyf A, Verlinden L, Segaert S, et al. Nonclassical effects of 1α,25-dihydroxyvitamin D3 and its analogs. Miner Electrolyte Metab,1999, 25(4-6): 345-348.
-
4Provvedini DM, Tsoukas CD, Deftos LJ, et al. 1, 25-Dihydroxyvitamin D3 receptor in human leukocytes. Science, 1983, 221 (4616):1181-1183.
-
5Veldman CM, Cantoma MT, DeLuca HF, et al. Expression of 1, 25-dihydroxyvitamin D3 receptor in the immune system. Arch Biochem Biophys, 2000, 374(2): 334-338.
-
6Ponsonby AL, McMichael A, van der Mei I. Untraviolet radiation and autoimmune disease: insights from epidemiological research. Toxicology, 2002, 181-182: 71-78.
-
7Deluca HF, Cantoma MT. Vitamin D: its role and uses in immunology. FASEB J, 2001, 15(14) : 2579-2585.
-
8Yang S, Smith C, Prahl JM, et al. Vitamin D deficiency suppresses cell-mediated immunity in vivo. Arch Biochem Biophys, 1993, 303(1): 98-106.
-
9Panda DK, Miao D, Tremblay ML, et al. Targeted ablation of the 25-dihydroxyvitamin D 1 alpha-hydroxylase enzyme: evidence for skeletal,reproductive, and immune dysfunction. Proc Natl Acad Sci USA,2001, 98(13) : 7498-7503.
-
10Abrams SA, Griffin IJ, Davila PM. Calcium and zinc absorption from lactose-containing and lactose-free infant formulas. AM J Clin Nutr,2002,76(2) : 442-446.
共引文献6
-
1麻继臣,张晓岚,郝礼森,刘娜.维生素D与炎症性肠病的研究进展[J].世界华人消化杂志,2008,16(23):2637-2643. 被引量：4
-
2李娟,黎友伦.1,25-二羟维生素D_3对结核杆菌感染的免疫调节作用[J].中国人兽共患病学报,2010,26(11):1059-1061. 被引量：3
-
3孙惠娟.毛细支气管炎患儿血清骨碱性磷酸酶测定及临床意义[J].南京医科大学学报（自然科学版）,2011,31(9):1307-1309. 被引量：1
-
4唐佳运,乔逸.维生素D与免疫调节和人类疾病关系研究进展[J].中国免疫学杂志,2014,30(12):1721-1725. 被引量：28
-
5许彩青,周雪飞.类风湿关节炎患者血清中25-羟维生素D检测的临床意义[J].现代实用医学,2015,27(8):995-996. 被引量：3
-
6Rui Han,Yuxuan Wang,Guanlu Li,Yiyu Cai,Zhilu Li,Yaqi Huang,Saijia Li,Pingping Yan.Research Progress on the Relationship between Polymorphism and SLE of Vitamin D Metabolic Pathway Related Gene[J].Journal of Human Physiology,2021,3(1):3-10.
-
1樊薇.正常人和骨质疏松患者的肠钙吸收[J].中国骨质疏松杂志,1996,2(1):48-48. 被引量：2
-
2王学东.“吃”掉多余的胆固醇[J].现代健康人,2005,8(8):56-56.
-
3丰胸7宗罪[J].伴侣,2011(3):68-68.
-
4HOU Li-chao,QIN Ming-zhe,ZHENG Li-na,LU Yan,WANG Qiang,PENG Dao-rong,YU Xin-ping,XIN Yu-chang,JI Gen-lin,XIONG Li-ze.Severity of sepsisis is correlated with the elevation of serum high-mobility group box 1 in rats[J].Chinese Medical Journal,2009(4):449-454. 被引量：23
-
5莫浩联,张世英,黄慈林,李波.医院环境中细菌L型的研究分析[J].中国卫生检验杂志,2006,16(3):360-362. 被引量：5
-
6郝莉,张青丽,万建美,李冰燕,张增利.1,25(OH)_2D_3抑制卵巢切除小鼠骨髓中T淋巴细胞活化的研究[J].营养学报,2010,32(2):193-194.
-
7周建烈,陈炜俊,顾景范.21世纪维生素D健康新概念[J].营养学报,2009,31(3):209-212. 被引量：3
-
8赫凡.当心不良习惯导致弯腰驼背[J].自我药疗,2014,0(10):67-67.
-
9刘福平,韩英.抗生素在胃肠疾病中的应用进展[J].中国医师进修杂志,1993,16(8):36-38.
-
10华敏.甲型H1N1流感的启示[J].老友,2009,0(6):23-23.
