摘要
目的:优化甘草黄酮阿魏酸乳膏配方,建立乳膏质量控制参数。方法:采用反射线直角单纯形法,考察乳膏伸展性及稳定性,优化乳化剂卖泽52单-硬脂酸甘油酯及透皮促进剂二甲基硅油配方用量。结果:配方中卖泽52单-硬脂酸甘油酯(3∶2)为9.0%,二甲基硅油为2.5%,乳膏稳定,伸展性符合半流体乳膏特性。结论:该乳膏配方合理,质量稳定。反射线直角单纯形法配方试验设计,方法简单、适用,适合乳膏剂配方优化。
Objective： To optimize the formula of Glycyrrhiza flavonoid and ferulic acid cream and set up its quality control parameters.Method： Reflect-line orthogonal simplex method was used to optimize the main factors such as amount of Myrj52-glyceryl monostearate and dimethicone,based on the appearance,spreadability and stability of the cream.Result： 9.0%Myrj52-glyceryl monostearate（3∶2）and 2.5% dimethicone were chosen in prescription.The prepared cream presented a good stability after being placed 24 h at 5 ℃,25 ℃ and 37 ℃ respectively,and its spreadability suited with the property of semi-fluid cream.Conclusion： The formula of Glycyrrhiza flavonoid and ferulic acid cream Is suitable,and its quality is stable.The reflect-line orthogonal simplex method is suitable for the formula optimization of cream.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2010年第4期449-452,共4页
China Journal of Chinese Materia Medica
关键词
甘草黄酮阿魏酸乳膏
配方优化
伸展性
反射线直角单纯形法
Glycyrrhiza flavonoid and ferulic acid cream formula optimization spreadability reflect-line orthogonal simplex method
