改善胰岛素抵抗的中药活性成分及其作用机制研究进展

Research progress on IR improvement and acting mechanisms of active ingredients of traditional Chinese medicine

对胰岛素抵抗(IR)以及近3年来改善IR的中药活性成分及其作用机制进行综述。IR是2型糖尿病发生和进展的驱动因素,IR的发生有多种分子机制。现代研究表明,多种中药活性成分能通过不同的作用机制,改善IR达到降糖作用的目的。

The insulin resistance（IR） and the active ingredients of traditional Chinese medicine and their mechanisms to improve IR in the last 3 years are summarized.Retrieve,classify and arrange the recent documentations of china and abroad.IR can drive the occurrence and progress of type 2 diabetes mellitus（T2DM）,and there are several molecular mechanisms for the occurrence of IR.IR has been a research focus of diabetes,the control strategies of T2DM have been changed from the ＂hypoglycemic therapy＂ into ＂improve the IR and IR-related metabolic abnormalities,and make a comprehensive prevention and treatment of cardiovascular risk factors.＂ It is demonstrated by experiments that a variety of active ingredients of traditional Chinese medicine can improve IR through different mechanisms to treat diabetes mellitus.