中药地锦草酚性成分

Phenols from Euphorbia humifusa

目的：为研究中药地锦草抗HBV活性物质基础。方法：采用聚酰胺、大孔树脂、Sephadex LH-20，MCIGELCHP20P等色谱厅法，从地锦草70％乙醇提取物中分离得到7个酚性化合物。结果：利用MS，NMR等波谱分析手段鉴定了化合物的结构，分别为：短叶苏木酚（brevifolin，1），短叶苏木酚酸（brevifolin carboxylicacid，2），短叶苏木酚酸甲酯（methyl brevifolincarboxylate，3），phyllanthussin E methylester（4），地榆酸双内酯（sanguisorbic acid dilactone，5），3，3’-二甲氧基鞣花酸（3，3’-2-di-O-methyleltagic acid，6），鞣花酸（ellagie acid，7）。结论：化合物2～6为首次从该植物中分得。

The investigation on the herbal of Euphorbia humifusa Wild. was carried out to find its anti-HBV constituents. The isolation and purification were performed by chromatography such as macroporous resin, polyamide, Sephadex LH-20, MCI GEL CHP 20P and so on. Based on the spectral analysis, seven phenols were identified as brevifolin（1）, brevifolin carboxylic acid（2）, methyl brevifolincarboxylate （3）, phyllanthussin E methyl ester （ 4 ）, sanguisorbic acid dilactone （ 5 ）, 3,3＇-2-di-O-methyl ellagic acid （6）, ellagic acid （7）. Among them, Compounds 2-6 were isolated from this plant for the first time.