从分子机制研究抗帕金森病中药的线虫模型

Study of molecular mechanism of anti-Parkinson's disease Traditional Chinese Medicine using model of Caenorhabditis elegans

中药在治疗帕金森病方面取得了较好效果,但对其治病分子机制了解相对较少,而阐明其分子机制是了解其发挥功能的基础。采用适合分子机制研究的模式生物线虫转基因帕金森病模型,从分子机制探索中药抗帕金森病的机制,可能是行之有效的方法。本文简要介绍帕金森病分子机制研究进展,进而介绍线虫转基因帕金森病模型研究中药干预帕金森病的分子机制。

Parkinson＇s disease （PD） is a neurodegenerative disorder with a complex, multifactorial aetiology. The brains of patients affected with PD are characterized by a loss of neurons in dopamine neurons in the substantia nigra, decreasing of dopamine secretion, and the deposition of Lewy bodies （LBs） in the cytoplasm of remaining neurons. In China the data show that the incidence of Parkinson＇s disease increases at least 20 times in recent 20 years, and it makes things worse for the aging society. Developing good anti-PD drags to improve the patient＇s quality of life is particularly important. The treatment of PD using traditional Chinese medicine （TCM） has made remarkable effect, while the the molecular mechanisms of it is still not known, while elucidating the molecular mechanismof TCM is the base of better understanding its function. Using genetically modified PD model of Caennrhabditis elegans, which is suitable for molecular mechanism study, to explore the interference mechanism of TCM to PD might be an eftective way. This review briefly introduces the research progress on molecular mechanism of PD, and then discusses the idea of using （2 elegans to study molecular mechanism of TCM intervention to PD.