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赖诺普利聚乙烯醇微粒的制备及其质量评价 被引量:3

Preparation and Quality Evaluation of Lisinopril Polyvinyl Alcohol Particles
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摘要 目的:制备赖诺普利聚乙烯醇微粒并评价其质量。方法:以聚乙烯醇为载体,采用喷雾干燥法制备赖诺普利聚乙烯醇微粒。考察制剂的形态、粒径、跨度、载药量、包封率和体外溶出度。结果:所制赖诺普利聚乙烯醇微粒为近球形,表面有孔,平均粒径为17.29μm,跨度为0.88,载药量为31.40%,包封率为94.20%,30min时体外累积溶出百分率达90%以上。结论:该制剂制备工艺简单,重复性好,质量检测指标合格。 OBJECTIVE: To prepare lisinopril-loaded polyvinyl alcohol (PVA) particles (LIS-PVA-P) and establish its quality control method. METHODS: LIS-PVA-P was prepared by spray-drying process with PVA as carrier. The preparation was detect- ed in terms of morphology, particle size, span, drug-loading capacity, encapsulation and in vitro dissolution. RESULTS: The preparation assumed sphere with porous surface. The average particle size was 17.29μm while drug-loading capacity 31.40%, encapsulation 94.20%, Span was 0.88, 90% of the drug loads were released within 30 min. CONCLUSION: The preparation process is simple, good in repeatability and qualified in quality.
作者 吴俊珠 金拓
出处 《中国药房》 CAS CSCD 北大核心 2010年第9期825-828,共4页 China Pharmacy
基金 云南省教育厅科研基金资助项目(09Y0379)
关键词 赖诺普利 聚乙烯醇 微粒 喷雾干燥法 制备 质量评价 Lisinopril Polyvinyl alcohol Particles Spray-drying process Preparation Quality evaluation
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  • 1Wald N J, Law MR. A strategy to reduce cardiovascular disease by more than 80% [J].BMJ, 2003, 326 (7 404) : 1 419.
  • 2Jin T, Pennefather P, Lee PI. Lipobeads: a hydrogel anchored lipid vesicle system[J].FEBS Letters, 1996,397 ( 1 ) : 70.
  • 3Kim C J, Lee PI. Synthesis and characterization of suspension-polymerized poly(vinyl alcohol) beads with coreshell structure[J].Journal of Applied Polymer Science, 1992, 46(12): 2 147.
  • 4Kim CJ , Lee PI. Composite polyvinyl alcohol beads for controlled drug delivery[J].Pharmaceutical Research, 1992, 9(1):10.
  • 5赵大庆,谭金权.聚乙烯醇微球的制备与研究[J].中国新药杂志,2005,14(2):181-184. 被引量:13
  • 6Ozmen L, Langrish TAG, Gipps EM. Spray drying pharmaceutical products for nasal delivery: The effects of feed solution properties and operating conditions on particle size and density Heat and Mass Transfer Australasia Proceedings of the Sixth Australasian: Heat and Mass Transfer Conference[C]. New York: Begell House, 1998: 427.
  • 7The United States Pharmacopeial Convention. The United States Pharmacopeia[S].USA :Rockville, 2005:1 139.
  • 8Bouabdallah S, Trabelsi H, Bouzouita K, et al. Reversed-phase liquid chromatography of lisinopril conformers [J]. J Biochem Biophys Methods, 2002,54( 1-3 ) : 391.
  • 9Kocijan A, Grahek R, Kocjan D, et al. Effect of column temperature on the behaviour of some angiotensin converting enzyme inhibitors during high-performance liquid chromatographic analysis[J].J Chromatogr B, 2001, 755 (142): 229.

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