期刊文献+

高密度脂蛋白防治动脉粥样硬化的新进展 被引量:5

下载PDF
导出
摘要 研究证实,HDL与冠心病风险呈负相关,同时,HDL潜在的抗动脉粥样硬化(AS)功能,使其成为AS性心血管疾病预防和治疗的主要靶向。但是2007年ILLUMINATE研究结果显示,胆固醇酯转运蛋白(CETP)抑制剂torcetrapib虽然能大幅增高HDL-C水平,但是torcetrapib组的死亡人数反而较对照组增多,差异有统计学意义,
出处 《中华老年心脑血管病杂志》 CAS 北大核心 2010年第3期272-274,共3页 Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
基金 广东省社会发展领域科技计划项目(2008B030301158) 南方医科大学南方医院院长重点基金(2008A003)
  • 相关文献

参考文献2

二级参考文献63

  • 1[1]Santamaina-fojo S, Pterson K, Knapper C, et al. Complete genomic sequence of the human ABCA1: analysis of the human and mouse ATP binding cassette promoter A. Proc Natl Acad Sci, USA, 2000, 97 (14): 7987-7992
  • 2[2]Vaisman BL, Lambert G, Amar M, et al. ABCA1 over expression leads to hyperalphalipoproteinemia and increased biliary cholesterol excretion in transgenimic mice. J Clin Invest, 2001, 108 (2): 303-309
  • 3[3]Reddy ST, Hama S, Ng C, et al. ATP-binding cassette transporter 1 participates in LDL oxidation by artery wall cells.Arterioscler Thromb Vasc Biol, 2002, 22 (11 ): 1877-1883
  • 4[4]Lawn RM, Wade DP, Couse TL, et al. Localization of human ATP binding cassette transporterl (ABCA1) in normal and atherosclerotic tissue. Ateroscler Thromb Vasc Biol, 2001,21 (3): 378-385
  • 5[5]Langmann T, Klucken J, Reil M, et al. Molecular cloning of the human ATP binding cassette transporter1 (h ABCA1):evidence for sterol dependent regulation in macrophages.Biochem Biophys Res Commun, 1999, 257 (1): 29-33
  • 6[6]Schwart K, Lawn RM, Wade DP. ABC1 gene expression and ApoA1 mediated cholesterol sterol efflux are regulated by LXR. Biochem Biophys Res Commun, 2000, 274 (3): 794-802
  • 7[7]Wade DP, Owen JS. Regulation of the cholesterol efflux gene ABCA1. Lancet, 2001, 357 (9251): 161-163
  • 8[8]Huuskonen J, Vishnu M, Pullinger CR, et al. Regulation of ATP-binding cassette transporter A1 transcription by thyroid hormone receptor. Biochemistry, 2004, 43 (6): 1626-1632
  • 9[9]Luo Y,Tall AR. Sterol upregulation of human CETP expression in vitro and in transgenic mice by an LXR element. J Clin Invest, 2000, 105 (4): 513-520
  • 10[10]Repa JJ, Berge KE, Pomajzl C, et al. Regulation of ATP-binding Cassette Sterol Transporters ABCG5 and ABCG8 by the Liver X Receptors alpha and beta. J Biol Chem 2002, 277 (21): 18793-18800

共引文献347

同被引文献65

引证文献5

二级引证文献14

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部