不同糖耐量及肥胖人群中血浆apelin水平及相关因素分析

Analysis of apelin level and related factors in patients with obesity and different glucose tolerances

目的评价肥胖、不同糖耐量人群中血浆apelin(APJ endogenous ligand)水平,探讨apelin与BMI、血脂、血糖等的相关性。方法根据糖耐量试验结果,将120例观察对象分为糖耐量正常(NGT)组、糖耐量受损(IGT))组和新诊断2型糖尿病(T2DM)组。上述三组又按BMI再各自分为正常体重(NW,BMI<25kg/m^2)与超重/肥胖(OW/Ob,BMI≥25kg/m^2)亚组,比较上述三组及各亚组之间血浆中空腹及服用75克葡萄糖后2h apelin的水平,同时检测血糖及血脂,计算BMI。结果三组空腹及糖负荷后2h apelin差异均有统计学意义(P<0.05或P<0.01),且IGT组和T2DM组的OW/Ob亚组患者apelin水平均高于NGT的OW/Ob亚组。BMI、FPG和SBP是血浆apelin的独立影响因素(P<0.05或P<0.01)。结论血浆apelin水平与Ob及T2DM有关。

Objective To evaluate apelin level in patients with obesity and different glucose tolerances, investigate relevance of apelin with body mass index（BMI）, blood lipid and blood glucose. Methods According to different glucose results of oral glucose tolerance test, 120 subjects were divided into three groups： normal glucose tolerance（NGT）, impaired glucose tolerance（IGT） and type 2 diabetes（T2DM）. All of the subjects were also divided into obese and non-obese subgroups based on their BMI（≥25kg/m2 or 〈25kg/m2 ）. Plasma apelin levels were compared among groups of NGT,IGT and T2DM. Fasting plasma glucose（FPG）and 2h postprandial plasma glucose （2hPG） after OGTT, lipid profile and BMI were measured. Results Both fasting and 2h postprandial plasma apelin had significant differences in these groups （P〈0. 05, or P〈0. 01）. The overweight and obese subgroups in the IGT group and diabetes group had higher apelin levels than their counterpart subgroups in the NGT group. BMI, FPG, systolic blood pressure（SBP） were independent influencing factors for apelin （P〈0. 05,or P〈0. 01）. Conclusions Plasma apelin level is related to obesity and type 2 diabetes.