摘要
妊娠期胰岛素抵抗(IR)易导致妊娠期糖尿病,胰岛素通过与其受体结合可在不同组织细胞内激活不同的信号途径而产生不同的作用。因而信号转导的不同环节出现异常均可导致IR。作为胰岛素信号转导中的关键酶,磷脂酰肌醇3激酶(phosphatidylinositol3-kinase,PI3K)在调节糖代谢中起到重要作用。PI3K信号通路减弱或受阻,使胰岛素生理作用减弱,导致IR形成,进一步发展为妊娠期糖尿病。针对此信号通路的深入研究有利于进一步阐明妊娠期糖尿病的发病机制并为临床治疗提供新思路。
Insulin resistance （IR） in pregnancy is prone to induce gestational diabetes mellitus （GDM）.Insulin exerts its physiological action by binding with insulin receptor,then activating different signal transduction pathways in some tissue cells and producing different effects.Therefore any link of the signal transduction pathway which appears abnormal possibly causes insulin resistance.As a key enzyme in insulin signal transduction,the phosphatidylinositol 3-kinase （PI3K） plays an important role in the regulation of glucose metabolism.If decreased or obstructed,the PI3K activity may affect the physiological role of insulin inducing insulin resistance,and then leading to gestational diabetes mellitus.Further study of the pathway will be useful to elucidate the pathogenesis of GDM and provide a new idea for the clinical treatment.
出处
《国际妇产科学杂志》
CAS
2010年第1期23-26,共4页
Journal of International Obstetrics and Gynecology
关键词
妊娠期糖尿病
磷脂酰肌醇3激酶
胰岛素抵抗
Gestational diabetes mellitus
Phosphatidylinositide3-kinase
Insulin resistance
