FHA的热物性能及生物活性研究

Thermophysical properties and bioavtivity reaearch of FHA

采用沉淀-煅烧法制备了F掺杂HA的FHA(Ca10(PO4)6(OH)2-2xF2x,0≤x≤1)粉末。通过X射线衍射(XRD)、热重分析(TG)、高温膨胀仪,扫描电镜(SEM),能谱仪(EDS)以及模拟体液浸泡实验研究了F掺杂对FHA高温热稳定性,高温烧结性能,热膨胀系数和生物活性的影响。结果表明,F掺杂能够提高FHA的高温热稳定性,且随F掺杂量增加,其稳定性逐渐提高;少量F(x=0.25)掺杂提高了HA基体的烧结致密度,随F含量增加(x>0.25),烧结致密度下降;F掺杂能降低FHA高温热膨胀系数(CET),随着F含量的增加,FHA的CET值减小。类骨磷灰石在块体表面的生长能力为FHA>HA>FA,其中x=0.5和0.75的FHA具有最好的生物活性。

FHA（Ca10（PO4）6（OH）2-2xF2x,0x1） powders were synthesized by wet precipitation-calcination method.XRD,TG,high-temperature dilatometer,SEM,EDS and SBF experiment were used to investigated the influences of F doping on the thermal stability and sintering properties of high temperature,thermal expansion coefficient,and bioactivity of FHA.The results show that doping F improves the thermal stability of FHA at high temperature,and the stability can be gradually improved with the inrease of F content;Sintering density of FHA bulk increases with small amount of F doping （x=0.25）,but decreases when F doping content more than x=0.25.Thermal expansion coefficient（CET） of FHA decreases with the increase of F content. The growth ability of bone-like apatite forming on FHA bulk surface proved by the SBF soaking experiment is ： FHAHAFA,and both F0.5HA and F0.75HA have the best bioactivity.