双氯灭痛壳聚糖水凝胶微球的制备及其性能研究

Preparation and characterization of voltraren chitosan hydrogel microspheres

在Span80与植物油形成的反相胶束体系中,通过戊二醛交联制备出壳聚糖水凝胶微球(CHM)。采用红外光谱和透射电镜等方法对CHM结构及粒子形态进行了研究。同时对CHM的溶胀度及其对模型药物双氯灭痛的体外释放行为进行了考察。结果表明,CHM具有较好的控制药物释放的作用。交联程度对微球粒径、溶胀度及药物释放性能影响较大。

Chitosan hydrogel microspheres （CHM） cross-linked with glutaraldehyde have been prepared in Span80/soja salad oil reverse micellar system. The structural characterization and the shape of the cross-linked CHM were studied by TEM and IR methods. Additional,the swelling degree of CHM and the release behavior of voltraren loaded in CHM in vitro were also studied. The results show CHM shows the satisfying function of controlling drug release. The diameter,the swelling degree and the capability of loading drug and controlling release of CHM depend largely on the cross-linking degree.