摘要
目的:评价文拉法新与舍曲林治疗抑郁症疗效的差异。方法:对6项符合纳入标准的研究应用循证医学方法评价文拉法新与舍曲林治疗抑郁症疗效有效率、以及症状学变化的差异。结果:文拉法新组的有效率(122/177 vs 128/179,OR=1.22,95%CI:0.77~1.93,Z=0.86,P>0.05)与曲林组相似,但是文拉法新组在第1周末(WMD:-1.57,95%CI:-2.98^-0.15,Z=2.17,P=0.03)和第2周末(WMD:-1.53,95%CI:-2.83^-0.23,Z=2.30,P=0.02)症状改善明显于舍曲林,而在第6周末相似(WMD:0.13,95%CI:-0.91~1.17,Z=0.25,P=0.81)。结论:文拉法新与舍曲林治疗抑郁症有效率相似,但前者症状改善前2周改善比较快。
OBJECTIVE： To evaluate the efficacy of welafaxine v.sertaline in the treatment of depression.METHODS： 6 studies meeting our criteria were analyzed with the use of evidence-based medicine method,with the curative efficacy such as the effective rate and the change in symptoms of welafaxine vs.sertaline evaluated comparatively.RESULTS： There were no significant differences in effective rate between welafaxine and sertaline（122/177 vs.128/179,OR=1.22,95% CI： 0.77~1.93,Z=0.86,P0.05）,whereas the symptom improvement in venlafaxine-treated group at 1st weekend（WMD：-1.57,95%CI：-2.98^-0.15,Z=2.17,P=0.03） and 2nd weekend（WMD：-1.53,95%CI：-2.83^-0.23,Z=2.30,P=0.02） were significantly better than in sertraline group but this difference at 6th weekend was not significant（WMD： 0.13,95%CI：-0.91~1.17,Z=0.25,P=0.81）.CONCLUSION： The venlafaxine is similar to sertraline in effective rate for depression,but symptom improvement appeared earlier for the venlafaxine-treated patients in the initial two weeks＇ treatment of depression.
出处
《中国医院用药评价与分析》
2010年第1期47-49,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
