临床药师对阿司匹林安全性干预研究

Clinical Pharmacists' Intervention Study on Safety of Aspirin

目的:通过临床药师宣教,研究临床药师对药品不良反应的影响。方法:从高血压、糖尿病、冠心病、脑卒中、高血脂的患者中抽取服用阿司匹林者262例,制作《阿司匹林用药手册》及宣教幻灯片,向患者传播阿司匹林用药知识及减轻、减少药品不良反应措施。选取的患者在宣教、随访、讲课等干预前后,分别进行B超检查并测定出凝血时间、血常规、肝功能、肾功能。结果:干预前后胃肠道反应、出血倾向、血栓形成倾向、肝功能异常发生率降低显著,肾功能异常、神经系统反应、凝血障碍发生率也有所降低。临床药师干预前不良反应发生率约12.21%,干预后降低到3.82%。患者用药依从性从干预前的23.48%提升到干预后的69.05%。结论:临床药师可以减少、减轻药品不良反应,提高患者用药安全性和用药依从性。

OBJECTIVE： To study the effect of clinical pharmacists＇ intervention including propaganda and instruction on the occurrence of adverse drug reactions.METHODS： 262 patients with hypertension,diabetes,coronary heart disease,stroke or hyperlipemia treated with aspirin were sampled,and ＂Medication Manuals of Aspirin＂ and lantern slide for propaganda and instruction were made in order to spread the medication knowledge about aspirin among patients and instruct them how to reduce the adverse reactions of aspirin.Blooding time,clotting time,routine blood test,liver function and kidney function were measured before and after the implementation of the intervention measures including propaganda instruction,follow-up and lecture etc.RESULTS： After intervention,the incidences of gastrointestinal reactions,bleeding tendency,thrombophilia,abnormal liver function were reduced significantly,and the incidence rates of abnormal kidney function,nervous system reactions and coagulopathy reduced to some degree;and the incidence of adverse reactions reduced from 12.21% to 3.82% and patients＇ medication compliance rose from 23.48% to 69.05%.CONCLUSION： Clinical pharmacists＇ intervention is conducive to the reduction and mitigation of adverse drug reactions as well as the improvement of patients＇ medication safety and medication compliance.