78例药物性肝病临床分析

Drug Induced Liver Disease:Clinical Analysis of 78 Cases

目的:分析药物性肝病的临床特点,提高临床医生对该病的认识。方法:对我院2004年1月～2008年10月78例药物性肝病患者的临床资料进行回顾性分析。结果:引起药物性肝病的药物中最多的为抗生素25例(32.05%)、其余依次为中草药24例(30.77%)、非甾体抗炎药14例(17.95%)、抗甲状腺功能亢进及降糖药7例(8.97%)、心血管用药5例(6.41%)、减肥药2例(2.56%)、化疗药1例(1.28%);肝细胞损伤型46例(58.97%)、胆汁淤积型6例(7.69%)、混合型26例(33.33%)。结论:引起药物性肝病的药物以抗生素、中草药及非甾体抗炎药为主,其临床特点与病毒性肝炎相似,并无特异性,早期诊断是关键,重点在预防。

OBJECTIVE：To analyze the characteristics of drug induced liver disease and improve clinicians’ cognition on this disease. METHODS： The clinical data of a total of 78 patients with drug induced liver disease hospitalized in our hospital between Jan 2004 to Oct 2008 were analyzed retrospectively. RESULTS： Of all the drugs that induced liver disease,antibiotics dominating the list with 25 cases （32.05%）,followed by Chinese herbal medicine with 24 cases （32.77%）,NASIDS [14 cases （17.95%）],antithyroidagents and glucose-lowing agents [7 cases （8.97%）],cardiovascular drugs [5 （6.41%）],antiobesity agents [2 （2.56%）],traditional Chinese medicines [1 case （1.28%）];46 cases （58.97%） were hepatocellular damage type;6 cases （7.69%） cholestasis type,and 26 cases （33.33%） mixed type. CONCLUSION： The drug induced liver disease is mainly caused by antibiotics/ Chinese herbal medicine and NASIDS. The clinical characteristics of drug induced liver disease are nonspecific and which is similar to viralhepatitis,therefore,its early diagnosis is of utmost importance and its prevention should be emphasized.