Caveolae介导的跨细胞转运与血管内皮通透性

Role of caveolae-mediated transcytosis in endothelial hyperpermeability

由小凹（Caveolae）介导的白蛋白跨细胞转运在生理及病理状态下均起重要作用。非受体型蛋白酪氨酸激酶（Src）是这一转运过程的“分子开关”，Src激酶将糖蛋白60（Gp60）、小凹蛋白-1（Caveolin-1，Cav-1）及发动蛋白-2（Dynamin-2）磷酸化，启动内吞过程；炎症状态下，中性粒细胞通过细胞间黏附分子-1（ICAM-1）激活Src激酶，从而促进Caveolae介导的白蛋白转运。

Caveolae-mediated albumin transcytosis plays an important role in physiological and pathological conditions. The events initiating transcytosis have been shown to be tightly regulated by non-receptor type Src family kinases, and thus Src signaling is thought to be a critical ＂switch＂ regulating caveolae-mediated transcellular transport of the plasma protein albumin. The activation of Src induces phosphorylation of glycoprotein 60, caveolin-1 and dynamin-2, and initiates transcytosis. In response to inflammatory stimuli, neutrophil adhesion to vascular endothelial cells via ICAM-1 （Intercellular adhesion molecule-1 ）cause Src activation which enhances caveolae transcytosis of albumin.