慢性阻塞性肺疾病患者骨骼肌功能障碍与氧化应激

Skeletal muscle dysfunction and oxidative stress in patients with chronic obstructive pulmonary disease

近年来慢性阻塞性肺疾病（chronicobstructive pulmonary disease，COPD）的全身表现引起关注，尤其是营养不良、体质量减轻、骨骼肌功能障碍等与COPD患者预后密切相关。氧化应激不但是COPD的发病机制之一，也是导致其骨骼肌功能障碍的重要原因，而运动本身可以诱发和加重COPD患者局部和全身的氧化应激，使病情复杂化。抗氧化治疗是COPD治疗的新靶点，为COPD的运动康复治疗带来了新课题。

Recently extrapuhnonary or systemic effects of chronic obstructive pulmonary disease （COPD） such as malnutrition, weight loss and skeletal muscle dysfunction attract more and more attention,which correlate with mortality of COPD. Oxidative stress is not only one of the important pathogenesis of COPD, but also mechanism of skeletal muscle dysfunction in patients with COPD. Exercise induced local or systemic oxidative stress complicates the disease itself, and antioxidants as a novel target in treatment of COPD bring us new research program.