运动对高血压大鼠血浆尾加压素Ⅱ及前列腺素I2的影响

Impact of exercise training on plasma UⅡ and prostaglandin I2 in spontaneously hypertensive rats

目的:研究运动对自发性高血压大鼠(SHR)血浆尾加压素Ⅱ(UⅡ)的影响。方法:雄性SHR16只,随机分为两组,即安静对照组(8只)和运动组(8只),另正常雄性Wistar大鼠(8只)作为正常对照组。SHR运动组进行8周游泳运动训练。8周后,分别测定3组鼠血浆UⅡ、前列腺素Ⅱ(PGI2)含量。结果:SHR游泳组大鼠血浆UⅡ含量较正常对照组显著性增加[(1.17±0.17)ng/ml∶(1.09±9.77)ng/ml,P<0.05],SHR游泳组血压较SHR对照组显著下降[(157.6±7.06)mmHg∶(185.9±6.64)mmHg,P<0.01],血浆PGI2含量较SHR对照组患者增加[(183.25±43.46)pg/ml∶(135.43±22.13)pg/ml,P<0.01]。结论:适度运动能提高SHR血浆VⅡ、PGI含量,从而使舒血管物质增多,血压下降。

Objective：To study the impact of exercise training on plasma UⅡ and prostaglandin I2 in spontaneously hypertensive rats （SHR）.Methods：The 16 male SHR rats were randomly divided into two groups：SHR control group （8,without exercise training） and SHR exercise group （8,with exercise training）. Normal male Wistar rats （8） as the normal control group. SHR exercise group swimming training for 8 weeks. The blood pressure,content of UⅡ and PGI2 in plasma were detected.Results：After exercise training the blood pressure in SHR exercise group significantly decreased than that of SHR control group[（157.6±7.06）mmHg vs.（185.9±6.64）P〈0.01]. Plasma UⅡconcentration of SHR exercise group significantly increased than that of normal control group[（1.17±0.17）ng/ml vs.（1.09±9.77）ng/ml,P〈0.05）; plasma PGI2 content of SHR exercise group significantly increased than that of SHR control group[（183.25±43.46）pg/ml vs.（135.43±22.13）pg/ml,P〈0.01].Conclusion：The result prompt that,exercise training induce Plasma UⅡconcentration increase,and increasing plasma PGI2 content,so decline blood pressure.