紫杉醇脂质体联合香菇多糖腔内注射治疗恶性胸腹腔积液疗效分析

Efficacy of paclitaxel liposome combined with lentinan injected cavity in the treatment of malignant pleural and peritoncal effusion

目的探讨紫杉醇脂质体联合香菇多糖治疗恶性胸、腹腔积液的疗效。方法26例伴发恶性胸、腹腔积液的晚期肿瘤患者．经细管闭式引流放胸、腹水后，给予紫杉醇脂质体90mg、香菇多糖4mg稀释后胸腹腔注入，3—7d后重复，间歇3周为一疗程；如胸、腹腔积液仍未控制甚至增加，则进行第二疗程治疗，用药及用法同第一疗程。结果紫杉醇脂质体联合香菇多糖治疗恶性胸、腹腔积液总有效率为73％，其中胸腔积液有效率为80％，腹腔积液有效率为68．8％．患者体质状况，经Karnofsky评分提高≥10分者达80．8％，而且局部及全身毒副作用轻。结论紫杉醇脂质体联合香菇多糖腔内注入治疗恶性胸、腹腔积液疗效满意，毒副作用轻，患者耐受良好，生活质量明显提高。

Objective To investigate the curative efficacy of Paclitaxel Liposome combined with Lentinan in the treatment of malignant pleural or peritoneal effusion. Methods 26 patients with advanced tumors concomitanted malignant pleural or peritoneal effusion, Closed drainage with tubules drained hydrothorax and ascites, Paelitaxel Liposome （90 mg） and Lentinan（4 mg） were perfused to thoracic or abdominal cavity, repeated after 3 -7 days, intermittent 3 weeks as a course of treatment;if pleural or peritoneal effusion did not controlled or even increased,continued the second course of treatment, the medication and usage were same to the first course of treatment. Results The total effective rate of Paclitaxel Liposome combined with Lentinan in the treatment of malignant pleural or peritoneal effusion was 73%, including pleural effusion rate 80%, peritoneal effusion rate 68.8%, The Karnofsky score which increased ≥ 10 score compared with the pretreatment were up to 80.8%, and this methods got minor side effect in the local and systemic. Conclusion The curative efficacy of Paclitaxel Liposome combined with Lentinan which were perfused to thoracic or abdominal cavity for malignant pleural or peritoneal effusion is satisfaction, with minor side effect, the patients are well tolerated and their quality of life improved obviously.