甲基强的松龙联合血液灌流治疗百草枯中毒的临床疗效观察

The clinical effects of methylprednisolone combined hemoperfusion in the treatment of paraquat poisoning

目的探讨大剂量甲基强的松龙联合血液灌流治疗重症百草枯中毒的临床疗效。方法2005～2008年经诊治的重症百草枯中毒患者155例．分为常规治疗组和强化治疗组。常规治疗组给予常规治疗，强化治疗组在常规治疗基础上加用甲基强的松龙300mg静脉滴注，每天1次，连用5d，后改为120mg，每天1次，视病情再应用2～3周至逐渐减量停药。分别于中毒后7d、14d、21d和12周进行疗效评价。所有的患者入院后都要检查三大常规、心肌酶谱、动脉血气分析，动态观察肺部CT。结果中毒后7d、14d、21d和12周强化治疗组患者不同服毒剂量其存活率均明显高于常规治疗组（P〈0．01）。结论采用大剂量甲基强的松龙联合血液灌流强化治疗重症百草枯中毒的临床疗效明显优于常规治疗。

Objective To investigate the clinical effects of high -dose methylprednisolone combined hemoperfusion in the treatment of severe paraquat poisoning. Methods 2005 - 2008 by the diagnosis and treatment of patients with severe paraquat poisoning in 155 eases, divided into conventional treatment group and group therapy. Conventional treatment group given conventional treatment, intensive therapy group in the conventional treatment based on the use of methytprednisoloue 300 mg intravenous drip,once a day,five days of MS,later renamed the 120 mg,once a day,depending on the condition again Application of 2 - 3 weeks to gradually reduce drug withdrawal. In poisoning after 7 days, 1,4 days,21 days and 12 weeks for evaluation. All patients admitted to hospital ＇after the inspection should routine of the three,myocardial enzymes,arterial blood gas analysis,observation of dynamic lung CT. Results Of poisoning after 7 days, 14 days,21 days and 12 weeks of intensive therapy group of patients differeut doses of poison their survival rate were significantly higher than conventional treatment group（ P 〈0.01 ）. Conclusion Of high - dose methylprednisolone combined hemoperfusion paraqual poisoning strengthen the treatment of severe clinical efficacy is superior to conventional treatment.