盐酸戊乙奎醚抢救重度有机磷中毒疗效分析

The comparison of the effect of penehyclidine hydrochloride （Penehyclidine） and atropine in the emergency treatment of severe acute organophosphorus pesticide poisoning patients

目的比较盐酸戊乙奎醚（长托宁）与阿托品抢救重度有机磷中毒患者的疗效。方法干预性的将重度有机磷毒物中毒患者分成两组，并在其他条件和方法不变的情况下，选择盐酸戊乙奎醚救治为治疗组，阿托品救治为对照组。比较两组的治愈率、病死率、严重并发症的发生率及严重并发症的病死率等指标。结果对照组总治愈率为77．8％，总病死率为22．2％，严重并发症的发生率为72．2％，严重并发症的病死率为30．8％。治疗组总治愈率为90％，总病死率10％，严重并发症的发生率为45％，严重并发症的病死率为10％。结论两组治愈率、总病死率及严重并发症发生率差异有统计学意义。盐酸戊乙奎醚能进一步减少严重并发症的发生，降低病死率，提高治愈率。用法用量较阿托品明显容易控制和掌握，可取代阿托品作为常规抗胆碱类解毒剂使用。

Objective Tu compare the effect of penehyclidine hydrochloride （Penehyclidine） and atropine in the emergency treatment of severe acute organophosphorus pesticide poisoning patients. Methods Phosphate poisoning patients were divided into two groups, with other conditions and methods in the same circumstances, penehyclidine hydroehloride treatment for the treatment gronp, atropine treatment for the control group. The cure rate, mortality, the incidence of serious complications and fatality rate of severe complications and so on were compared between the two groups. Results The overall cure rate of the control group was 77.8%, lotal mortality was 22.2%, the incidence of serious complications was 72.2%, and the fatality rate of severe complications was 30. 8% in the control group. The total cure rate was 90%, total mortality was 10%, the incidence of serious complications was 45%, the fatality rate of severe complications was 10% in the treatment group. Conclusion The cure rate, iotal mortality rate and incidence of serious complications of the two groups have a significant difference. Penehyclidine hydrochloride can further reduce the incidence of serious complications and reduee mortality, improve the cure rate. Penehyelidine hydrochlorlde （Penehyclidine） significantly is better than atropine in the control and mastery. Penehyelidine hydrochloride can be used to replace conventional anticholinergic atropine as an antidote to the use of categories.