摘要
目的通过检测慢性心力衰竭(chronic heart failure,CHF)患者和非心力衰竭对照者血浆正五聚蛋白3(pentraxin 3,PTX3)水平,探讨血浆PTX3在CHF中的临床意义。方法按Framinghan诊断标准入选CHF患组66例,非心力衰竭对照组20例。采用酶联免疫吸附测定法检测两组血浆PTX3水平。结果CHF组血浆PTX3水平明显高于非心力竭衰对照组,(3.3±1.4)μg/L vs(1.8±0.6)μg/L(P<0.01);CHF组血浆PTX3水平随纽约心脏病学会(NYHA)心功能分级增加而上升(P<0.01);CHF患者血浆PTX3水平与左心室舒张末期内径(LVEDD)呈正相关(r=0.431,P<0.01),与左心室射血分数(LVEF)呈负相关(r=-0.452,P<0.01)。结论血浆PTX3水平高低反映慢性心力衰竭的炎症程度,并随心功能的恶化而升高。
Objective To research the clinical significance by testing the plasma pentraxin 3 （PTX3） level in patients with chronic heart failure. Methods Plasma pentraxin 3 levels in 66 patients with heart failure and 20 control subjects without heart failure were measured by sandwich enzyme-linked immunosorbent assay. The diagnosis of heart failure was based on the Framingham criteria for heart failure. Results Plasma PTX3 concentration was significantly higher in patients with heart failure than in control subjects,（3.3±1.4） μg/L vs （1.8±0.6） μg/L （ P 〈0.01） ,and increased as the severity of New York Heart Association（NYHA） functional class advanced （P 〈0.01）. Line correlation analysis revealed that plasma PTX3 concentration correlated positive with left ventricular end-diastolic dimension（ r = 0. 431, P 〈 0.01 ）, but negative with left ventricular ejection fraction （ r =-0. 452, P 〈 0.01 ）. Conclusion The level of plasma PTX3 not only reflects the degree of inflammation of heart failure,but also elevates with the extent of the deterioration of cardiac function.
出处
《临床荟萃》
CAS
2010年第5期380-382,共3页
Clinical Focus
