过敏体质与非过敏体质患者冠状动脉病变差异的比较

Comparison of the lesions of coronary artery in high allergic patients and Non-high-allergic patients

目的通过冠脉造影研究过敏与非过敏体质患者冠状动脉病变的差异，并比较上述两类人群血脂水平的差异，探讨血脂调节影响冠脉斑块形成过程的免疫机制。方法对过敏与非过敏体质组各40例可疑冠心病患者行血脂检测，并行冠脉造影进行对比分析。结果过敏体质组与非过敏体质组之间冠脉单支及无病变、双支病变、多支病变概率分布差异有统计学意义（χ^2=6．024，P〈0．05），冠脉局限性病变、弥漫性病变概率分布差异有统计学意义（χ^2=6．084，P〈0．05），冠脉轻度及以下狭窄、中度狭窄、重度狭窄概率分布差异无统计学意义（P〉0．05）。过敏体质组TC[（4．56±1．96）mmol／L]及LDL—C[（2．56±0．65）mmol／L]水平低于非过敏体质组[TC（4．89±3．51）mmol／L，LDL—C（3．81±1．93）mmol／L]，差异有统计学意义（P〈0．05），TG及HDL—C水平差异无统计学意义（P〉0．05）。结论过敏体质者可优化脂质代谢，进而减少可能出现的冠脉事件或使冠脉斑块形成趋于局限化。

Objective Compare the lesions of coronary angiography and levels of blood lipid in patients with high allergic and non-high allergic, and to explore the role of immune mechanisms in formation of coronary plaque through regulating lipid. Methods The results of blood lipid levels of 40 patients with irritability history and 40 patients without irritability history who suspect coronary heart disease were analyzed. Two groups were given selective coronary angiography （SCAG） and compared the results of angiography imaging. Results The probability distribution of lesions of single branch （including non-disease）, two branches and three branches between allergic group and non-allergic group were statistical significant （χ^2=6.024,P〈0.05）, the probability distribution of localized lesions and generalized lesions between two groups were statistical significant （χ^2=6.084,P〈0.05）,the probability distribution of mild stenosis（including non-stenosis）, moderate stenosis and severe stenosis between two group were no significant difference （P〉0.05）, the levels of TC （4.56±1.96）mmol/L and LDL-C （2.56±0.65） mmol/L of allergic group were lower than that of non-allergic group[ （4.89±3.51）mmol/L, （3.81±1.93）mmol/L], the difference were statistically siguificant（P〈0.05 ）, TG and HDL-C levels between two groups were no significant difference（P〉0.05 ）. Conclusion The state of hypersensitivity tend to optimize lipid metabolism, and thus reduce the coronary events may occur or to tend to limit the formation of coronary plaque.