123株肺炎链球菌血清分型及耐药性研究

Resistance and Serotype of 123 Strains of Streptococcus Pneumoniae

目的了解成都地区123株肺炎链球菌(Streptococcus Pneumoniae,S.p)对常用抗菌药物的耐药性及血清分型。方法用Kirby-Bauer纸片扩散法测定S.p对6种抗菌药物的敏感性,用荚膜肿胀试验进行血清分型。结果123株S.p中,耐阿奇霉素发生率为100%;对米诺环素、复方新诺明、氯霉素、利福平、氧氟沙星的耐药率分别为65.04%、78.05%、19.51%、0.81%、0;血清分型共涉及11个血清型/群,主要集中在19、6、14、15、23血清群,5株S.p未能分型,多重耐药菌株分布在6、19血清群。结论S.p耐药严重,且大多数菌株呈多重耐药趋势;血清分型居前6位的是19F、6、14、15B/C、23F、19A,尤其是多重耐药株以6、19血清群为主。

Objective To investigate antibiotic resistance and the prevalence of serotype of Streptococcus pneumoniae. Methods Totally 123 strains of S. pneumoniae were collected to test the susceptibility of 6 antibiotics by K-B method according to the standard of CLIS. Serotyping of S. pneumoniae was performed by using quelling reaction. Results Among 123 strains of S. pneumoniae, all strains （ 100% ）were resistant to AZM. There were 65.04%, 78.05%, 19.51%, 0.81%0, 0% of S. pneumoniae were resistant against the MH, SXT, C, RA, OFX respectively. 11 serotypes were involved in 123 strains. The prevalent serogroup were 6, 14, 15, 19 and 23.5 strains were unable to serotype. The muhi-resistant strains of S. pneumoniae included in serogroup 6 and 19. Conclusion The antibiotic resistance of S. pneumoniae is very, serious. Most of them are multi-resistant strains. The prevalent serogroup, especially of the multi-resistant strains, are 6 and 19 serogroup.