2型糖尿病微血管并发症与非高密度脂蛋白胆固醇关系的临床研究

Study of relationship between non-HDL-C and microvascular complications with type 2 diabetes meUitus

目的探讨非高密度脂蛋白胆固醇与2型糖尿病微血管并发症的关系及临床价值。方法选择2型糖尿病患者120例，并将其分为糖尿病无血管并发症组60例（B组）和糖尿病微血管并发症组60例（c组），另选择正常对照组100例（A组），检测各组血脂并计算非高密度脂蛋白胆固醇（non-HDL—C）。结果A组、B组、C组non—HDL—C水平依次升高，且差异有统计学意义（P〈0．05）；运用ROC曲线对B组、C组的血脂指标进行分析显示，non—HDL—C的曲线下面积最大，为0．638，且两组间比较差异有统计学意义（P〈0．05），临床应用价值较大。结论non—HDL—C的增高是糖尿病微血管并发症的危险因素，有较高的临床应用价值。

Objective To explore the relationship of non-HDL-C and microvascular complications with type 2 diabetes mellitus and analyze the clinical application value of non-HDL-C. Methods 120 patients with T2DM were enrolled in the study：60 patients without mirovascular complications （group B）, 60 patients with microvascular complications （ group C ）, meanwhile 100 individuals as normal controls （ group A）. Blood lipids were measured and non-HDL-C was calculated. Results The level of non-HDL-C was successively increased in group A, B and C, and there was significant difference among these three groups （P 〈 0.05） ; Using ROC curve to analyze the clinical application value of non-HDL-C in patients with microvascular complications of T2DM, we found that compared with group B, non-HDL-C had the largest area undercurve of 0.638 in group C and had significant difference （ P 〈 0.05 ）. Conclusion The increase of non- HDL-C was the risk factor for microascular complications of T2DM and had high clinical application value.