华桑茎皮的化学成分研究

Chemical constituents in stem bark of Morus cathayana

目的对桑科植物华桑Morus cathayana茎皮进行化学成分研究。方法利用色谱方法进行化学成分分离和纯化，采用波谱和化学等方法鉴定结构；并对分离得到的部分化合物进行细胞毒活性筛选。结果分离并鉴定了11个黄酮类化合物，分别鉴定为粗毛甘草素F（glyasperin F，1）、broussoflavonol F（2）、胡枝子黄烷酮C（lespedezaflavanone C，3）、异甘草黄酮醇（4）、桑根醇B（sanggenol B，5）、sanggenol L（6）、sanggenol D（7）、sanggenol G（8）、sanggenol A（9）、二氢槲皮素（10）、槲皮素（11）。结论化合物1～3为首次从该属植物中分得。化合物2、4～6和9对5种人癌细胞表现出细胞毒活性，其IC50值为0．41～7．2μg／mL。

Objective To study chemical constituents in The constituents were separated and purified with chr0ma elucidated by spectroscopic methods and chemical analyses. toxicities. Results Eleven compounds, glyasperin F （1）, the stem hark of Morus cathayana. Methods tographic methods and their structures were All the compounds were tested for their cytobroussoflavonol F （2）, lespedezaflavanone C （3）, isolicoflavonol （4）, sanggenol B （5）, sanggenol L （6）, sanggenol D （7）, sanggenol G （8）, sanggenol A （9）, dihydroquercetin （10）, and quereetin （11）, were isolated from the stern bark of M. cathayana. Conclusion Compounds 1--3 are isolated from Morus L. for the first time. Compounds 2, 4--6, and 9 exhibit moderate cytotoxic activities against five human cancer cells with the IC50 value of 0. 41--7. 2μg/mL