LDL在荷瘤小鼠体内的分布及TNF、胆酸对其分布的影响

Distribution of I 125 -LDL in S180-soft-bearing Mice and its Modification by TNF of Bile acid

目的：研究低密度脂蛋白（ＬＤＬ）在荷瘤小鼠体内的分布及ＴＮＦ、胆酸对其分布的影响。方法：将１２５Ｉ－ＬＤＬ由荷瘤小鼠尾静脉注入，γ计数器测所取各组织放射活性并观察ＴＮＦ和胆酸对其影响。结果：肿瘤组织对ＬＤＬ的摄取量较高；ＴＮＦ和胆酸均可降低肝、肾组织对ＬＤＬ的摄取量（Ｐ＜０．０５）；两者联用更可提高肿瘤组织对ＬＤＬ的摄取量（Ｐ＜０．０５）。结论：肿瘤组织对ＬＤＬ的摄取量较高；用药可以增加肿瘤组织对ＬＤＬ的摄取量。提示ＬＤＬ有可能作为一种良好的抗肿瘤药物载体。

Objective:This study examines the potential value of low density lipoprotein (LDL) as a vehicle for targeting cytotoxic drugs to tumor cells in S180-soft-bearing mouse model systems. Methods:The mice were injected with I 125 -LDL. 18 h later the animals were killed and sampled from a series of organs. We investigated the radioactivities assimilated by the tissues of liver,kidney,lung,spleen,heart,muscle,adrenal,gland,brain,bone,blood and tumor.Results:The uptake of LDL in tumor were higher than that of most studied tissuses except liver,kidney and adreal gland. TNF and bile-acid can diminish the concertration of LDL in liver and kidney, and combined administration of the two can enhance LDL focusing on tumor tissuses without affecting the others.Conclusion:LDL could be a potential vehicle of antitumor drug and the selectivity of LDL to tumor can be promoted by modification of reasonable medication.