子宫组织ER、PR及PCNA的表达与子宫平滑肌瘤的关系

Research on the Relationship between the expression of progesterone Receptor and proliferating Cell Nuclear Antingen to Uterine Leiomtoma in the Uterine Tissues

目的：探讨性激素在子宫平滑肌瘤发病中的作用，为临床治疗平滑肌瘤提供理论基础。方法：应用免疫组化ＳＰ法检测分析了４６例子宫肌瘤、肌层、内膜组织雌激素受体（ＥＲ）、孕激素受体（ＰＲ）、增殖细胞核抗原（ＰＣＮＡ）的含量。结果：子宫肌瘤组织中ＥＲ、ＰＲ、ＰＣＮＡ的含量显著高于正常肌组织，ＥＲ、ＰＲ明显低于内膜增生期（Ｐ＜０．０５，Ｐ＜０．００１）。结论：子宫肌瘤的发生与雌、孕激素的水平及其受体的含量有关，ＰＣＮＡ可能与肿瘤的异常生长有关。

Objective:Our purpose wes to identify the role of hormones in the pathogesis of uterine leiomyoma to provide theoretical basis for medical treatment.Methods:Estrogen receptor(ER),progesterone receptor(PR) and proliferating cell nuclear antigen(PCNA) of uterine leiomyoma,normal myometrium and endometrium were quantitatively analysed by immunohistochemical SP method in 46 specimens obtained from women undergoing hysterectomy.Results:The expression of ER and PCNA were significantly higher in leiomyoma than those in normal myometrium(P<0.01).In the leiomyoma whereas,the expression of ER were significantly lower than those in proliferative phase (P<0.01),the expresssion of PCNA were also significantly lower in proliferative phase and myometrium than those in secretory phase and leiomyoma(P<0.005,P<0.001 respectively).Conclusion:The pathogenesis of uterine leiomyoma correlated with estrogen, progesterone levels and expression of receptor in the uterine tissuse.The abnormal growth and development of leiomyoma is believed to be affected by PCNA.