血清γ-谷氨酰转肽酶活性与原发性肝癌的关系(附50例临床分析)

Relationship Between Serum γ-Glutamyl Transpeptidase Activity and Primary Hepatocarcinoma—An Analysis of 50 cases

目的：因原发性肝癌（ＨＣＣ）是国内最常见的恶习性肿瘤之一，血清甲胎蛋白（ＡＦＰ）虽已被公认是早期诊断ＨＣＣ的敏感性标记物，但仍有少部分ＨＣＣ患血清ＡＦＰ含量仍低档于正常值。笔者据血清γ－谷氨酰转肽酶（γ－ＧＴ）与ＡＦＰ均有癌胚特性的原理，而针对性观察了ＨＣＣ的血清γ－ＧＴ活性。方法：设５０例ＨＣＣ患者为观察组，并设５０例肝炎后肝硬化患者为照组，观察其血清γ－ＧＴ活性及γ－ＧＴ与谷氨转肽酶（ＡＬＴ）的比值。结果：观察组血清γ－ＧＴ／ＡＬＴ比值明显高于对照组（Ｐ＜０．０１）。结论：此观察提示。

Objective:The serum γ-glutamyl transpeptidase activity was observed in 50 patients with primary hepatocarcinoma to understand their relationships.Methods:An observation group of 50 patients with primary liver cancer was made along with a control group of 50 patients with posthepatitic cirrhosis. The two groups were observed for the activity of serum γ-glutamyl transpeptidase(γ-GT) and the ratio of γ-GT to ALT.Results:The ratio was clearly higher in the observation group than in the control.Conclusion:Serum γ-GT: ALT ratio is of some value to the early diagnosis of primary hepatocaicinoma.