摘要
The metastable state and nucleation kinetics of clindamycin phosphate (CP) in cooling crystallization were studied by metastable zone width (MZW) method and induction time method. By correlating the MZW experimental results with temperature, agitation rate and cooling rate, it is found that the correlation result shows good agreement with the change trend of MZW. The critical nucleation parameters were evaluated based on the classical theory of nucleation; both the interfacial tension and the radius of critical nucleus increased with the decrease of relative supersaturation. The effect of supersaturation on the nucleation rate was analyzed. It is indicated that the new phase formation of CP is governed by mononuclear mechanism.
The metastable state and nucleation kinetics of clindamycin phosphate （CP） in cooling crystallization were studied by metastable zone width （MZW） method and induction time method. By correlating the MZW experi- mental results with temperature, agitation rate and cooling rate, it is found that the correlation result shows good agreement with the change trend of MZW. The critical nucleation parameters were evaluated based on the classical theory of nucleation; both the interfacial tension and the radius of critical nucleus increased with the decrease of rela- tive supersaturation. The effect of supersaturation on the nucleation rate was analyzed. It is indicated that the new phase formation of CP is governed by mononuclear mechanism.
基金
Supported by the Program of Introducing Talents of Discipline to Universities (No. B06006)
