中老年血尿酸水平与代谢综合征的相关性研究

Relationship between serum uric acid concentration and metabolic syndrome in elderly Chinese

2007年至2008年在我院进行健康体检者中，随机选取50岁以上近2年无吸烟史、不饮酒或偶尔饮酒（1—2次／月），并剔除其中严重心脑血管疾病者、已诊断为糖尿病并治疗者、高血压应用利尿剂治疗者、近3月服用降脂药者以及肝、肾功能异常者，共911例。资料分析显示，男性高尿酸血症的患病率为20．56％（140／681），女性为22．17％（51／230），代谢综合征（按修订的NCEP标准）的患病率分别为35．83％（244／681）和32．17％（74／230）。血尿酸水平与腰围（r=0．331）、收缩压（r=0．219）、舒张压（r=0．208）、甘油三酯（r=0．181）呈正相关，与高密度脂蛋白胆固醇（r=-0．375）呈负相关。随着代谢异常项目的增加，血尿酸水平显著升高。logistic回归分析显示随着血尿酸浓度的升高，代谢综合征的患病危险也在升高。

A cross sectional study was conducted based on the data collected from annual health check in 2007-2008 in our hospital. Total 911 subjects, including 681 men and 230 women aged over 50, with no history of smoking and alcohol consumption less than 1 - 2 times/month were enrolled in the study. Subjects were excluded, if they had history of severe cardiocerebral vascular disease, diabetes mellitus under drug treatment, hypertension with diuretics or anti-hyperlipidemic treatment for last 3 month, and hepatic and/or renal dysfunction. The results showed that the prevalence of hyperuricemia in this population was 20. 56% （140/681） and 22. 17% （51/230） for men and women respectively, and the prevalence of metabolic syndrome by NCEP criteria was 35.83% （244/681） and 32. 17% （74/230）. Correlation analysis demonstrated that serum uric acid levels were positively correlated with waist circumference （r = 0. 331 ） , systolic BP （ r = 0. 219 ） , diastolic BP （ r =0. 208 ） , TG （ r = 0. 181 ）, and negatively correlated with HDL-C （ r = - 0. 375 ）. Serum uric acid levels increased significantly with the numbers of metabolic syndrome components. Logistic analysis showed that higher serum uric acid concentrations significantly increased the risk of metabolic syndrome.