枯草杆菌二联活菌肠溶胶囊联合小剂量阿米替林治疗肠易激综合征疗效观察

Therapeutic effect in the treatment of IBS with live combined bacillus subtilis and enterococcus faecium enter-coated capsules and low dose amitriptyline

目的观察枯草杆菌二联活菌肠溶胶囊联合小剂量阿米替林治疗肠易激综合征的疗效及毒副反应。方法将123例肠易激综合征患者随机分成三组,三组病例具有可比性,治疗组43例,给予阿米替林12.5 mg,每晚睡前服用,枯草杆菌二联活菌肠溶胶囊0.5 g,每日3次;单用阿米替林组39例,口服阿米替林12.5 mg,每晚睡前服用;单用枯草杆菌二联活菌肠溶胶囊组41例,枯草杆菌二联活菌肠溶胶囊0.5,每日3次。治疗4周后三组进行疗效比较。结果治疗组总有效率86.05%,单用阿米替林组总有效率71.79%,单用枯草杆菌二联活菌肠溶胶囊组总有效率67.44%,治疗组与对照组比较,差异有统计学意义(P<0.05),单用阿米替林组总有效率与单用枯草杆菌二联活菌肠溶胶囊组相比,差异无统计学意义。三组患者均未发现明显的不良反应。结论枯草杆菌二联活菌肠溶胶囊联合小剂量阿米替林治疗肠易激综合征简明、经济,毒副作用小,值得临床推广应用。

Objective To observe the therapeutic effect and adverse reaction in the treatment of IBS with live combined bacillus subtilis and enterococcus faecium enter - coated capsules and low dose amitriptyline. Methods 123 cases of IBS patients was divided into 3 groups randomly, cases of all groups had comparability. Treatment group had 43 cases, and 12.5 rag amitriptyline quaque nocte and 0.5 g live combined bacillus subtilis and enterococcus faecium enter - coated capsules three times a day was given to every cases of this group. Only amitriptyline group had 39 cases which 12. 5 mg amitriptyline quaque nocte was given to every cases of this group. Only live combined bacillus subtilis and enterococcus faecium enter - coated capsules group had 41 cases which 0.5 g live combined bacillus subtilis and enterococcus faecium entercoated capsules three times per day was given to every case. Results Total effective rate of treatment group was 86. 05%, total effective rate of only amitriptyline group was 71.79%, total effective rate of only live combined bacillus subtilis and enterocoecus faecium enter - coated capsules group was 67.44%. The difference between treatment group and control group were statistically signifieant（P 〈0. 05）. There were no significant differences between only live combined bacillus subtilis and enterococcus faecium enter - coated capsules group and only amitriptyline group. There were no obvious adverse effect in all the three groups. Conclusion With live combined bacillus subtilis and enterococcus faecium enter - coated capsules and low dose am- itriptyline to treat irritable bowel syndrome（IBS） is concise, economy, little side effect. It is very deserve clinical generalization and application.