阿立哌唑与利培酮治疗80例精神分裂症对比

Aripiprazole and risperidone in the treatment of 80 cases of schizophrenia in contrast

目的：采用阿立哌唑与利培酮治疗80例精神分裂症对比。方法：收集我院2007年1月至2009年10月间送检病理的80例精神分裂症患者的临床资料。阿立哌唑组40例，男28例，女12例，平均年龄（33．7±9．9）岁，平均病程（2．0±0．7）个月；利培酮组40例，男25例，女15例，平均年龄（30．5±12．2）岁，平均病程（1．9±0．6）个月。结果：本组病例就诊后24h内即明确诊断者60例（75％），就诊后2～4d内明确诊断者20例（25％）。两组差异无显著性（P〉0．05）。两组PANSS总分及各因子分在治疗后均显著下降（P〈0．01），但两组相比，差异无显著性（P〉0．05）。阿立哌唑组痊愈20例（50％），显著进步10例（25％），进步8例（20％），无效2例（5％），有效率95％，显效率75％；利培酮组痊愈15例（37．5％），显著进步13例（32．5％），进步6例（15％），无效6例（15％），有效率85％，显效率70％。阿立哌唑治疗精神分裂症引起的并发症共计13例，占到了32．5％；利培酮治疗精神分裂症引起的并发症30例，占到了75％。结论：阿立哌唑组有效率和显效率均优于利培酮组。利培酮治疗精神分裂症引起的并发症率大大高于阿立哌唑组。

Objective ： Aripiprazole and risperidone in the treatment of 80 cases of schizophrenia in comparison. Methods ： in our hospital from January 2007 to October 2009 between the submission of the 80 cases of pathological clinical data of patients with schizophrenia. Aripiprazole group of 40 patients, 28 males and 12 females, average age （33. 7 ± 9. 9） years of age, with an average duration of （2.0± 0.7 ） months; risperidone group of 40 patients, male 25, female 15 cases, mean age （30.5 ±12.2） years, with an average duration （ 1.9 ± 0.6） months. Results： The patients in this group 24 h after treatment within a definite diagnosis in 60 cases （75%）, 2 - 4 d after treatment within a definite diagnosis in 20 cases （25 % ）. There was no significant difference between the two groups （P 〉 0.05）. PANSS total score and the factor scores of the two groups after treatment were significantly decreased （P 〈 0.01 ）, but the two groups, no significant difference （P 〉 0.05）. Aripiprazole group cured 20 cases （50%）, significant improvement in 10 patients （25%）, progress in 8 cases （20%）, 2 cases （5%）, efficiency 95% , markedly effective rate was 75% ; Risperidone ketone group cured 15 cases （37.5%）, signifi cant improvement in 13 cases （32.5%）, progress in 6 cases （ 15% ）, ineffective in 6 cases （ 15% ）, efficiency 85%, markedly effective rate was 70%. Aripiprazole in the treatment of schizophrenia caused by complications of a total of 13 cases, accounting for 32.5% ; risperi- done in the treatment of schizophrenia caused by complications of 30 cases, accounting for 75% ; Conclusion： Aripiprazole group efficiency and efficiency are all significantly better than the risperidone group. Risperidone in the treatment of schizophrenia is much higher than the rate of complications caused by aripiprazole group.