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UDP-GalNAc:多肽N-乙酰氨基半乳糖转移酶-14 被引量：4

UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 14
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摘要 UDP-GalNAc:多肽N-乙酰氨基半乳糖转移酶家族(简称GalNAc-T)是黏蛋白O-糖基化的起始酶,N-乙酰氨基半乳糖转移酶-14(GalNAc-T14)是该家族中最新发现的成员。近年来有人指出,O-糖基化可能与肿瘤的发生发展具有密切关系,因此对N-乙酰氨基半乳糖转移酶家族的研究也受到越来越多重视。本文主要综述了GalNAc-T14的命名、结构、分布、功能以及潜在的应用价值。 N-acetylgalactosaminyltransferases （GalNAc-Tases） catalyze the first step in the O-glycosylation of mucin proteins. GalNAc-T14 is a new member of glycosyltransferases family. Recent studies have demonstrated that O-glycosylation may be closely related to the carcinogenesis and development of turnouts. Hence, studies on the N-acetylgalactosaminyltransferase family are getting more and more attention. The nomenclature, structure, distribution, function and the potential application value of GalNAc-T14 was reviewed in this paper.
作者 郭晓丹 吴琛 康现江
机构地区 河北大学生命科学学院
出处 《生命的化学》 CAS CSCD 北大核心 2010年第1期27-32,共6页 Chemistry of Life
基金 国家自然科学基金项目(No.30800180) 河北省自然科学基金项目(No.C2009000191) 河北省教育厅科学研究计划(No.2008-106) 河北省科技支撑计划(No.07275552)资助
关键词 N-乙酰氨基半乳糖转移酶家族:GalNAc-T14 O-糖基化 肿瘤发生 N-Acetylgalactosaminyltransferases GalNAc-T14 O-glycosylation carcinogenesis
分类号 R730.2 [医药卫生—肿瘤]
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共引文献5

同被引文献90

  • 1沈宏杰,吴士良.多肽∶N-乙酰氨基半乳糖转移酶的结构和特性[J].生命的化学,2004,24(6):472-474. 被引量：3
  • 2胡鹤娟,吴艳,王浩森,秦芳,朱琍燕,吴士良.多肽:N-乙酰氨基半乳糖转移酶家族在不同生长阶段的小鼠脑中的mRNA表达差异[J].江苏大学学报（医学版）,2007,17(2):111-114. 被引量：1
  • 3Pegram MD,Borges VF,Ibrahim N,et al.Phase Ⅰ dose escalation pharmacokinetic assessment of intravenous humanized anti-MUC1 antibody AS1402 in patients with advanced breast cancer[J].Breast Cancer Res,2009,11 (5):R73.
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  • 6Pratt MR,Hang HC,Ten Hagen KG,et al.Deconvoluting the functions of polypeptide N-alpha-acetylgalactosaminyltransferase family members by glycopeptide substrate profiling[J].Chem Biol,2.004,11 (7):1009-1016.
  • 7Iwasaki H,Zhang Y,Tachibana K,et al.Initiation of O-glycan synthesis in IgAl hinge region is determined by a single enzyme,UDPN-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2[J].J Biol Chem,2003,278 (8):5613 -5621.
  • 8Landers KA,Burger M J,Tebay MA,et al.Use of multiple biomarkers for a molecular diagnosis of prostate cancer[J],Int J Cancer,2005,114(6):950-956.
  • 9Ishikawa M,Kitayama J,Kohno K,et al.The expression pattern of UDP-N-acetyl-alpha-D-galactosamine-pelypeptide N-acetyl-galactosaminyl transferase-3 in squamous cell carcinoma of the esophagus[J].Pathobiology,2005,72 (3):139-145.
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生命的化学
2010年 第1期

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