氧化胁迫环境下的酵母细胞应答调控

Cellular responds under oxidative stress in Saccharomyces cerevisiae

酿酒酵母细胞在生长过程中会不断受到内外环境的氧化攻击。活性氧族物质的累积能够损害细胞中的脂质、DNA和蛋白质,从而会影响细胞的正常功能,严重者将造成细胞死亡。为了对抗氧化胁迫,酵母细胞在不断地适应过程中,进化出了较为完整的保护机制,呈现出多水平多层次的应激应答反应。细胞在非酶水平、蛋白质水平和基因水平上协同作用,共同完成了活性氧族物质的清除和胁迫信号的传递应答。本文对酵母细胞在氧化胁迫环境下的应答调控做了简要综述。

Oxidative stress often uninterruptedly attack yeast cell which is process of growth. Accumulation of reactive oxygen species in the cell induces toxic damage to cellular components, such as protein, DNA and lipids, and it eventually leads to cell death. Therefore, the yeast cells have to evolve completely antioxidant systems to protect it from oxidative stress for survival and the systems show a rapid response in multilevel and multistrata. A number of antioxidant systems cooperate to clean up reactive oxidative species and transmit stress signal in non-enzymatic and enzymatic and genetic levels. This paper simply summarizes regulations of response to oxidative stress for Saccharomyces cerevisiae.