葡萄糖调节蛋白75的研究进展

Progress of study on glucose regulated protein 75

葡萄糖调节蛋白75(Grp75)是高度保守的热激蛋白家族中的一员,在细胞内主要行使伴侣蛋白的功能,帮助未折叠或错误折叠蛋白质进行正确的折叠,还与细胞内多个因子结合,参与细胞内多个重要的生物学过程。现就Grp75的基因定位、蛋白质分布和功能以及临床研究展开本综述。

Grp75 belongs to heat shock protein family with highly conservatism, Grp75, which is a member of the highly conserved heat shock protein family, mainly function as intracellular chaperones for other proteins. It plays important roles in assisting unfolded or mis-folded proteins to establish proper protein conformation. It also can bind to several other cellular factors and take part in several important cell biology processing. In this article, we reviewed the localization of Grp75 gene, the subcellular distribution and biological function of Grp75 protein as well as the research in clinics.