糖基磷脂酰肌醇锚定蛋白质与肿瘤血管生成的关系

Glycosylphosphatidylinositol-anchored protein and tumor angiogenesis

肿瘤血管生成是一个非常复杂的过程,涉及到多种因子的调节。目前,已发现多种糖基磷脂酰肌醇锚定蛋白质与肿瘤血管生成密切相关。尿激酶型纤溶酶原激活剂受体(urokinase plasminogen activator receptor,uPAR/CD87)、CD55、基质金属蛋白酶、T-钙黏着蛋白、RECK、Eph家族受体作用蛋白A(Eph family receptor interacting protein A,ephrin A)等均能调节肿瘤血管生成过程。本文对糖基磷脂酰肌醇锚定的调节因子如何影响肿瘤血管生成,以及它们作为肿瘤治疗的主要靶标研究进行综述,为肿瘤治疗的抗血管生成新靶标的设计提供信息。

Angiogenesis is a very complicated process regulated by many kinds of factors. Presently, it has been found that occurrence of angiogenesis were closely correlated with glycosylphosphatidylinositol-anchored proteins, including CD87, CD55, MMP, T-cadherin, RECK, and ephrinsa A. This article summarizes the GPI-anchored regulated factors affecting tumor angiogenesis and current targets of anti-angiogenesis for tumor therapy, which will provide information for designing new anti- angiogenesis targets used in tumor therapy.