西洛他唑与银杏叶提取物治疗糖尿病周围神经病变对比临床观察

Cilostazol and Ginkgo Biloba Extract Treatment of Diabetic Peripheral Neuropathy Clinical Observation of Contrast

[目的]对比西洛他唑(培达)与银杏叶提取物治疗糖尿病周围神经病变(DNP)的临床疗效。[方法]将46例DNP患者随机分为培达组23例,银杏叶组23例。两组均经糖尿病教育、饮食控制、合理运动、降糖药物及胰岛素强化治疗,血糖基本平稳后,两组均予甲钴胺注射液500μg肌肉注射,每日1次,银杏叶组加用银杏叶提取物87.5mg加入生理盐水250mL内静滴每日1次;培达组加用西洛他唑0.2g加入生理盐水250mL内静滴每日1次,分别治疗15天。观察治疗后两组症状、体征并监测感觉神经和运动神经传导速度。[结果]治疗后两组症状均有改善,但培达组的效果更明显,两组间比较差异有显著性(P<0.05)。[结论]培达与银杏叶提取物治疗糖尿病周围神经病变均有临床疗效,但培达组优于银杏叶提取物组。

[ Objective ] Comparison of cilostazol （Peter Kam） and Ginkgo biloba extract treatment of diabetic peripheral neuropathy （DNP） of the clinical efficacy. [Methods] DNP will be 46 cases were randomly divided into group of 23 cases of Peter Kam, Ginkgo biloba group of 23 cases. The two groups were characterized by diabetes education, diet control, reasonable exercise, hypoglycemic drugs and intensive insulin therapy, blood glucose was stable, the two groups are related to Methylcobalamin 500p, g intramuscular injection once a day, Ginkgo biloba group received Ginkgo biloba extract material 87.5mg in 250mL normal saline int.ravenous infusion once a day ; Peter Kam Group was added 0. 2g of eilostazol in 250mL normal saline infusion once a day were treated for 15 days. Two groups of symptoms after treatment, signs and monitor sensory and motor nerve conduction velocity. [Results] Symptoms after treatment both groups improved, but the effect of Peter Kam Group is more obvious difference between the two groups was significant （ P 〈 0.05 ）. [ Conclusion ] Of eilostazol and ginkgo biloba extract treatment of diabetic peripheral neuropathy clinical effect is significant, but Peter Kam Group is better than ginkgo biloba extract.