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雌激素受体结合测试法在内分泌干扰物筛选测试中的应用

Application of Estrogen Receptor Binding Assay in the Endocrine Disrupting Chemicals Screening Tests
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摘要 雌激素受体结合测试法是利用某些化合物与17β-雌二醇竞争结合雌激素受体的能力,测定该化合物的雌激素活性。该测试方法具有简单、快捷,重现性好等优势。该文主要介绍了雌激素受体结合测试法的原理、研究进展、测试方法、影响因素及其应用前景。 Estrogen receptor binding assay is to assess the estrogenic activity of chemicals by determining the ability of competing with β-estradiol to bind with estrogen receptor. It has the strengths of simplicity, speediness with good reproducibility. This literature reviewed mainly the mechanism, the research progress, test method, influencing factors of this assay as well as its application.
出处 《环境与健康杂志》 CAS CSCD 北大核心 2010年第1期79-81,共3页 Journal of Environment and Health
基金 国家自然科学基金资助项目(40676067) 国家水体污染控制与治理科技重大专项资助项目(2008ZX07526-001)
关键词 雌激素受体结合测试法 内分泌干扰物 离体试验 Estrogen receptor binding assay Endocrine disrupting chemicals in vitro assay
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参考文献24

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