邻苯二甲酸酯类化合物的体内代谢及毒性研究进展

Advances in Researches on Metabolic Mechanism and Toxicity of Phthalate Esters

由于邻苯二甲酸酯类在环境中普遍存在,其一级代谢物邻苯二甲酸单酯在一些环境中也被发现。研究表明邻苯二甲酸单酯在体内的生物活性并不降低,已造成了对人体的伤害,成为研究邻苯二甲酸酯类毒性的新热点。该文介绍了邻苯二甲酸酯的代谢机制,对邻苯二甲酸单酯的三致毒性、生殖发育毒性、对激素及核受体家族的影响进行了综述。

Phthalate esters widely exist in the environment. It has been demonstrated that they are harmful to human bodies. Phthalate mono-esters are the first metabolite of phthalate esters. In general, biotransformation or metabolism of xenobiotics most frequently result in detoxification of the chemical and facilitates excretion from the body. However, this may not be the case for phthalates. In the present papers metabolism of phthalate esters and the toxicity of the phthalate mono-esters were reviewed, not only the effect of their mutagenesis, teratogenesis and carcinogenesis, but also their toxicity on reproduction, development, hormones, nuclear receptor, inflammation and obesity were included.