内皮素与血管内皮细胞生长因子在非小细胞肺癌中的表达及相关性

Correlation of VEGF and ET-1 Expression in Non-small Cell Lung Cancer and their Clinical Significance

目的研究内皮素(endothelin-1,ET-1)与血管内皮细胞生长因子(vascularendothelialgrowthfactor,VEGF)在非小细胞肺癌中的表达及两者的相关性。方法应用免疫组化SABC染色法,检测101例非小细胞肺癌标本中ET-1、VEGF的阳性表达,分别评价ET-1和VEGF与非小细胞肺癌临床病理特征间的关系,并分析ET-1和VEGF表达的相关性。结果 ET-1表达与肿瘤组织学分级、病理分期有关(P<0.05),与病理分型无关联;VEGF表达与肿瘤病理分期有关(P<0.05),与组织分级、病理分型无关联。ET-1高表达的区域VEGF也呈高表达,两者的表达呈正相关(P<0.05)。结论 ET-1和VEGF的表达与非小细胞肺癌的发生发展密切相关,可以作为该病恶性生长的检测指标。ET-1与VEGF可能具有协同作用,促进血管生成。

Objective To investigate the relationship between the expression of endothelin-1 and Vascular endothelial growth factor and its clinical significance in Non-small Cell Lung Cancer. Methods ET-1 and VEGF positive expressions in 101 samples of patients with non-small cell lung cancer were detected by immuno-histochemistry. Results The expression of ET-1 had a relation with histological grade, clinical staging of the lung cancer; and the expression of VEGF had a relation with clinical staging of the lung cancer. The Expression of ET-1 was significantly related with the expression of VEGF （all P〈0.05）. Conclusion ET-1 and VEGF may play an important role in the development of Non-small Cell Lung Cancer and might be used to evaluate the prognosis. ET-1 might coordinate with VEGF to promote angiogenesis.