乙酰肝素酶在子宫内膜癌组织中的表达及意义

Expression of Heparanase in Tissue of Endometrial Carcinoma

目的探讨乙酰肝素酶在子宫内膜癌组织中的表达及预后关系。方法采用S-P免疫组织化学法检测Hpa和CD34蛋白在子宫内膜癌组织和正常子宫内膜组织中的表达,并结合病理学分型、组织学分级、微血管密度(MVD)和临床分期探讨其意义。结果子宫内膜癌Hpa蛋白的表达显著高于正常子宫内膜(P<0.05),子宫内膜癌组织中Hpa蛋白的表达与子宫内膜癌组织血管生成、病理分型、分期有关(P<0.05)。结论Hpa蛋白在子宫内膜癌中呈高表达,并与子宫内膜癌血管生成、病理特征有关,检测其表达以对判断子宫内膜癌的生物学行为提供指标。

Objective To study heparanase （Hpa） expression in endometrial cancer tissue and the relationship of Hpa expression and prognosis. Methods Immunobistochemieal staining （SP method） was employed to detect the expression was of Hpa and CD34 protein in normal endometrial tissues and tumor tissues. Hpa protein expression was evalueted combining with pathological type, histologic grade, microvessel density （MVD） and clinical stage. Results The expression of Hpa protein in endome- trial carcinoma tissues was significantly higher than that in normal endometrial tissues （ P 〈 0. 05）. It was correlated with the angiogenesis, pathological type,classification of endometrial carcinoma （ P 〈 0. 05 ）. Conclusion Overexpression of the Hpa protein is related to the angiogenesis, pathological features of endometrial carcinoma. The determination of Hpa is useful to predict tumor biological behavior.