ET-1 SP-B在肺水肿组织中表达的研究

Study on the Expression of ET-1、SP-B in Pulmonary Edema

目的:探讨各型肺水肿病理形态改变及ET-1、SP-B表达对发病机制的相关性研究。方法:20例对照组病例因肺部肿瘤行右肺全切术,经病理学检查右肺中叶没有肿瘤细胞侵犯。76例尸检组光镜观察肺组织病理学改变,并应用免疫组化方法测定病例肺组织SP-B、ET-1的含量。结果:76例尸检组肺组织SP-B含量较对照组明显减少,ET-1含量明显增多(P<0.05)。结论:ET-1、SP-B在导致各型肺水肿发生的肺损伤中均有明显的相关性;ET-1、SP-B在各型肺水肿组织表达呈明显负相关性。

Objective： To study the role of ET -1 ,SP- B in the meehinic of disease in pulmonary edema. Method ：20 patients in control group was excised the fight line for lung cancer. 76 cases of autopsy group in pulmonary edema, by immunohistochemical method to study the role of SP - B, ET - 1 in lung tissue. Result： The results of the role of SP - B was decreased than the control group, and ET - 1 increased obviously （ P 〈 0.05 ）. Conclusion ： The role of ET - 1, SP - B is obviously related to pulmonary edema .