摘要
以2-氨基-5-氟硫酚为起始原料,经N-羰基-D-丙氨酸酐脱羧环合制得(R)-1-(6-氟-苯并噻唑-2-)乙胺(1);L-缬氨酸采取分步反应,经过酰胺化,羧基活化后与(1)反应,合成目标产物苯噻菌胺。反应总收率56.7%,含量96.6%(HPLC),产物经1HNMR、MS进行了表征。
Benthivalicarb-isopropyl was synthesized from 2-amino-5-fluorobenz-enethiol via decarboxylation, cyclization, amidation and carboxy activation. The total yield of benthivalicarb-isopropyl was 56.7%, and the content was 96.6%. The products were determined by 1H NMR and MS.
出处
《农药》
CAS
北大核心
2010年第3期174-175,178,共3页
Agrochemicals
关键词
杀菌剂
苯噻菌胺
2-氨基-5-氟硫酚
合成
fungicide
benthivalicarb-isopropyl
2-amino-5-fluorobenzenethiol
synthesis
