重度颅脑损伤术后抗生素相关腹泻的治疗

Treatment for antibiotic-associated diarrhea after severe brain injury surgery

目的探讨电解质饮料并双歧杆菌活菌对重度脑损伤术后抗生素相关性腹泻(AAD)的治疗作用。方法将66例重度脑损伤术后AAD患者随机分成2组:研究组予电解质饮料+双歧杆菌活菌治疗,对照组予常规补液+口服相应抗生素;在治疗前后观察抗生素使用情况,治疗期间观察患者体温、腹泻、血白细胞、电解质指标恢复时间及粪便细菌涂片。结果在2组抗生素使用率相同情况下,研究组疗效优于对照组(P<0.05)。结论应用电解质饮料+双歧杆菌活菌治疗AAD经济、疗效显著、患者恢复快、无毒副作用。

Objective It is to explore the curative effect of electrolyte drinks combined with Bifidobactcrium on the antibi- otic associated diarrbea （AAD） after severe brain injury surgery. Methods 66 cases of AAD patients after severe brain injury surgery were randomly divided into 2 groups： study group was treated with electrolyte drink ＋ Bifidobacterium, the control group was treated with conventional infusion ＋ oral antibiotics. Using of antibiotics before and after treatment was observed. Body temperature, diarrhea, blood white blood cells, electrolyte indicators and fecal bacteria smear during the treatment were observed. Results The curative effect of study group was better than that of control group（P 〉 0.05）, when the using rate of antibiotics were the same in both groups. Conclusion Application of electrolyte drinks combined with Bifidobacterium for the treatment for AAD was low-cost, significant effective, quick recovery of the patients without toxic side effects.